For Caregivers: Nourishing Holidays

Ah, “‘Tis the season….” But for many of us, it is another day of the same old thing, or, maybe worse, it is a time when there are even more expectations and responsibilities placed upon us than we usually face. May be they come from inside, or maybe they are expectations from others, none-the-less, the holiday season can be more burdensome than joyful for many of us.

Hopefully, you can make some time for yourself for inner reflection—Some time to consider things or people that you are grateful for and some things that you would like to do a little differently in your future. It may even be a little more important now that we are entering a new Millennium!

So, I invite you to consider your relationship with food! Some of you may scratch your head “Relationship” with food? I have relationships with people or pets, not food!” This may be true for the many of us who truly view food as a means of sustenance – You may know folks who truly don’t care what they eat and may even forget to eat, unless someone reminds them or prepares it for them. There are those of us, however, for whom foods, especially certain foods, seem to have a voice in our heads. It may sound like “I’m here waiting for you to eat me – please don’t leave me in this half empty bag (or container) in the dark all night” or “Oh, it’s the holidays and we both know I’m not good for you. Still, this once, just a little bit won’t hurt….”

As a nutritionist, I often speak to people about the nutrients and nutrition in the food they eat. I am growing in my understanding that there is a lot more to food than just the chemicals that make up the protein, fat, vitamins and minerals. In a book called Nourishing Wisdom, the author, Marc David, very nicely shows how the psychological and spiritual aspects of our lives affect how and if we are truly nurtured. In his book, Mr. David suggests that we need to experience food as a neutral thing – no “good” or “bad” food – and instead, listen to our bodies to know what to eat. The foods we humans eat are greatly influenced by our culture and psychology, rather than by instinct. Our bodies want, and need, different foods at different times. We prefer salads and light foods in the summer and soups and heavier foods during the colder, darker winter months. There may be times when we are happy or sad that we want a certain food, because it is familiar to us or associated with similar circumstances in our past.

At holiday times, we look forward to special foods. Why? For many of us, they remind of us happy times, special times and, perhaps, times when someone else was responsible for the cooking! These special foods have the capacity to nourish us in more ways than just giving us calories and vitamins and minerals. For each of us, we long to belong, to know we are important to someone or that we have made a difference in someone’s life. If, somehow, we are not sure of these things, we may turn to eating certain foods to feel comforted or to preparing foods for others to be sure we are needed and appreciated.

As we grow older, many of us are faced with chronic diseases like high blood pressure, heart disease or diabetes. We may find it harder to maintain our youthful figures… And still, each year the Holidays come around, luring us with their many treats, treats that often are not very healthy for us in the long run.

Instead of feeling compelled to eat one more cookie or sliver of pie, and then feel guilty about it, please consider this instead. Take a few seconds to ask yourself, “Am I really hungry for this? …How will I feel later, if I eat this now?” Or “Do I need it right this minute? Could I wait till later when I’m not so full?” It will just take a few seconds and it may save you from feeling bad for a lot longer later! And, as any thing new you try, you will forget sometimes. Do not worry about that! Celebrate the times you remember – Celebrate the times you remember to take care of yourself!

As you are shopping at the bakery or getting out your family’s favorite recipes full of butter and sugar, ask yourself, “How can I make this recipe a little healthier—and still taste good? What’s important here? Is it that we have the same foods that taste the same, or is it that we celebrate life and its many pleasures and treasures and challenges this past year has brought?” If that’s what the holidays are about, then it may not matter what foods are on the table, healthy or not. But it may matter, in the long run, if you feel good about yourself, because you know that taking care of your health and the health of your loved ones is a year round commitment.

 

Article from Today’s Caregiver.

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Experimental cancer drug repurposed for Parkinson’s

As promising as a drug candidate may be, the unfortunate truth is that not all of them end up performing as hoped – but that doesn’t mean they’re completely useless. Researchers at Oxford University have managed to give second life to an experimental cancer drug known as tasquinimod, which has now shown promise for Parkinson’s.

Tasquinimod emerged as a promising drug in fighting solid tumors, with most research focusing on using it to treat prostate cancer. The drug made it through to phase three clinical trials, but unfortunately it didn’t seem to extend overall survival rates in patients, and after those disappointing results development was discontinued for prostate cancer treatment.

But the work wasn’t for nothing – the clinical trials so far have shown that tasquinimod is well tolerated by the body, and it could still potentially help treat other illnesses, such as Parkinson’s disease.

To investigate the drug, the Oxford team first took skin cells from patients with a rare genetic form of Parkinson’s, and turned them into a type of stem cell known as induced pluripotent stem cells (iPS). From these the researchers grew brain cells in vitro, allowing them to observe progression of the disease in the lab.

The team found that the key may be an error with a protein known as HDAC4. When that happens, this protein begins to repress certain genes, which in turn messes with the brain cells’ ability to regulate the natural cycle of proteins. That means those proteins build up in the cells, which has long been known to contribute to Parkinson’s and related neurodegenerative diseases like Alzheimer’s.

Tasquinimod comes to the rescue by blocking HDAC4, meaning those key genes aren’t “switched off,” and effectively halting progression of the disease.

“We think that switching off these genes in brain cells may play a vital role in the cell damage and death that occurs in Parkinson’s,” says Richard Wade-Martins, co-lead author of the study. “Finding a way to ‘turn them back on’ with a drug could be a promising, unexplored way to develop new treatments.”

The researchers then repeated the study using iPS cells gathered from people with the more common non-genetic form of Parkinson’s, and found that the same pattern of inactive genes seems to be at play. That indicates that these people might also benefit from the treatment, although the team also acknowledges that some people don’t seem to respond to it.

“The study also highlights the growing number of drugs which can be repurposed from their original medical use to treat Parkinson’s,” says David Dexter, Deputy Director of Research at Parkinson’s UK, which funded the study. “Developing a drug from scratch is a long, slow and expensive process. By finding existing drugs and moving them rapidly into clinical trials, we can make them available for people with Parkinson’s much more quickly, easily and cheaply.”

Although that process may be streamlined, it is still early days for tasquinimod. The study has only been conducted on a total of 10 patients so far, so more testing will need to be done before it could become a viable treatment option.

The research was published in the journal Cell Stem Cell.

Article from New Atlas.

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Did George HW Bush have Parkinson’s?

The recent death of former president George HW Bush from vascular parkinsonism led many to question the difference between the condition and Parkinson’s disease. 

Parkinsonism is the umbrella term for conditions that mimic symptoms similar to those experienced by people living with Parkinson’s. Vascular parkinsonism can occur in people who have experienced a mild stroke, or have restricted blood supply to the brain. The condition causes symptoms similar to Parkinson’s – including rigidity, difficulties walking and problems with speech and memory.

While the symptoms of the two conditions are similar, vascular parkinsonism is not considered a progressive neurodegenerative disease.

Dr Michael Okun, professor of neurology at the University of Florida, said: “It can be tricky to differentiate Parkinson’s disease from vascular parkinsonism (due to stroke(s)). Many experts refer to stroke induced parkinsonism as lower body parkinsonism because it tends to affect the legs more than the arms. In practice the differentiation can be tricky and sometimes both entities actually coexist.”

 

Information from Parkinson’s Life.

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Parkinson’s to be included in new CDC database

Throughout the year, you’ve heard about a new database at the Centers for Disease Control (CDC) to collect vital demographic information on people living with neurological diseases. Earlier this fall, Congress gave the CDC funds to implement this database, called the National Neurological Conditions Surveillance System (NNCSS). The CDC recently announced that Parkinson’s is one of two diseases that will be included in the initial rollout of the NNCSS.

While there are rough estimates of the number of people diagnosed with Parkinson’s in the United States, we don’t have accurate and comprehensive information on how many people are living with the disease, who they are and where they are located. This lack of core knowledge can slow Parkinson’s research and therapeutic development. The NNCSS will be a valuable resource for collecting this information. The data could help scientists understand many aspects of the disease, such as clusters of diagnoses in certain geographic regions, differences in the number of men and women diagnosed with Parkinson’s, and variability in health care practices among patients.

Establishing the NNCSS will provide researchers with critical information on the impact of Parkinson’s disease in the United States. Through WPA’s participation in the Unified Parkinson’s Advocacy Council, we will offer the CDC information on Parkinson’s and the role the NNCSS can play in helping to further research. As the CDC releases updates about the database, we will share news with you.

Read more about the NNCSS on the CDC website.

 

 

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